Center Progress Year 1

Bruce S. Edwards, Tudor I. Oprea, Eric R. Prossnitz, and Larry A. Sklar. Flow cytometry for high-throughput, high-content screening. Current Opin. Chem. Biol. 8:392-398, 2004.

Marius M. Olah, Cristian G. Bologa, and Tudor I. Oprea. An Automated PLS Search for Biologically Relevant QSAR Descriptors. J. Comp.-Aided Mol. Design 18:437-449, 2004.

Marius M. Olah, Cristian G. Bologa, and Tudor I. Oprea. Strategies for Compound Selection. Current Drug Discovery Technologies 1: 211-220, 2004.

Tharun Kumar Allu and Tudor I. Oprea. Rapid Evaluation of Synthetic and Molecular Complexity for in Silico Chemistry.
J. Chem. Inf. Model 45(5):1237-1243, 2005.

Cristian Bologa, Tharun Kumar Allu, Marius Olah, Michael A. Kappler, and Tudor I. Oprea. Descriptor collision and confusion: Toward the design of descriptors to mask chemical structures. J. Comp.-Aided Mol. Design 19: 625-635, 2005.

Bruce S. Edwards, Cristian Bologa, Susan M. Young, Konstantin V. Balakin, Eric R. Prossnitz, Nikolay P. Savchuck, Larry A. Sklar, and Tudor I. Oprea. Integration of Virtual Screening with High-Throughput Flow Cytometry to Identify Novel Small Molecule Formylpeptide Receptor Antagonists.   Mol. Pharmacol. 68:1301-1310, 2005.

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, Eric R. Prossnitz, and Larry A. Sklar. Post-High-Throughput Screening Analysis: An Empirical Compound Prioritization Scheme.
Journal of Biomolecular Screening 10(5), 419-426, 2005.

Igor V. Tetko, Ruben Abagyan, and Tudor I. Oprea. Surrogate data – a secure way to share corporate data. J. Comp. Aid. Mol. Design 19: 749-764, 2005.

Susan M. Young, Cristian Bologa, Eric R. Prossnitz, Tudor I. Oprea Larry A. Sklar and Bruce S. Edwards. High-Throughput
Screening with HyperCyt® Flow Cytometry to Detect Small Molecule Formylpeptide Receptor Ligands. J. Biomol. Screen. 10(4), 2005.

Mathewos Tessema, Peter C. Simons, Daniel F. Cimino, Lilliana Sanchez, Anna Waller, Richard G. Posner, Angela Wandinger-Ness, Eric R. Prossnitz and Larry A. Sklar. Glutathione-S-Transferase-Green. Fluorescent Protein Fusion Protein Reveals Slow Dissociation from High Site Density Beads and Measures Free GSH Cytometry Part A 69A: 326-334, 2006.

Matthew J. Saunders, Heungbok Kim, Travis A. Woods, John P. Nolan, Larry A. Sklar, Bruce S. Edwards, and Steven W. Graves. Microsphere-Based Protease Assays and Screening Application for Lethal Factor and Factor Xa Cytometry Part A 69A: 342-352, 2006.

Cristian G. Bologa, Chetana M. Revankar, Susan M. Young, Bruce S. Edwards, Jeffrey B. Arterburn, Alexander S. Kiselyov, Matthew A. Parker, Sergey E. Tkachenko, Nikolay P. Savchuck, Larry A. Sklar, Tudor I. Oprea and Eric R. Prossnitz. Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat. Chem. Biol. 2: 207-212, 2006.

David G. Lloyd, Georgia Golfis, Andrew J. S. Knox, Darren Fayne, Mary J. Megan and Tudor I. Oprea. Oncology exploration: charting cancer medicinal chemistry space. Drug Discovery Today 11,
Number 3/4, 2006.

University of New Mexico flow cytometry research center